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Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. History of Lupus. Lupus Foundation of America.
June Related Articles. Your current browser may not support copying via this button. Subscriber sign in You could not be signed in, please check and try again. Username Please enter your Username. Password Please enter your Password. Forgot password? Don't have an account? Sign in via your Institution.
You could not be signed in, please check and try again. Sign in with your library card Please enter your library card number. In Payne used quinine in the treatment of patients with LE and postulated the presence of a vascular disturbance. In , Sequira and Balean published a large series of patients with discoid and systemic LE and provided clinical and pathologic details of a young woman who died of glomerulonephritis.
In , Jadassohn published an exhaustive review of discoid and systemic LE, including clinical features and pathologic findings.
Between and Sir William Osler published 29 cases of what was termed the erythema group of diseases. Spread Awareness. Get Local Support. Join Our Support Community. Shareable Toolkit.
Sign Up for Emails. Tell Your Story. Media Relations. Contact Us. Annual Report. National Lupus Partners Network. The history of lupus. Lupus in the classical period The history of lupus during the classical period was reviewed by Smith and Cyr in Furthermore, he enumerated various signs and symptoms which characterized the systemic form, including: subcutaneous nodules arthritis with synovial hypertrophy of both small and large joints lymphadenopathy fever weight loss anemia central nervous system involvement The existence of a systemic form of lupus was firmly established in by the work of Osler in Baltimore and Jadassohn in Vienna.
Lupus in the modern era present The sentinel event which heralded the modern era was the discovery of the LE cell by Hargraves and colleagues in First animal model developed Two other major advances in the modern era have been the development of animal models of lupus and the recognition of the role of genetic predisposition to the development of lupus.
Genetic component recognized The familial occurrence of systemic lupus was first noted by Leonhardt in and later studies by Arnett and Shulman at Johns Hopkins. Lupus therapies then and now Finally, no discussion of the history of lupus is complete without a review of the development of therapy. Looking forward The history of lupus, although dating back at least to the Middle Ages, has experienced an explosion in this century, especially during the modern era over the past 60 years.
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